Therapeutic Areas

We can use the PMM to test for bacterial adhesion to and host cell toxicity of experimental devices.

Our reactors are an excellent testing platform for materials in development. We can determine how bacteria will adhere, form biofilm, and grow in the presence of your experimental materials.

Since much of the human genital tract is composed of mucosal tissue, the PMM can be used for predictive preclinical testing of compounds or products related to urogenital health.

Porcine skin serves as a relevant model for wound care. The skin has comparable thickness, hair follicle density, and wound closure via reepithelialization.

By engineering wounds in our human skin model, we can investigate the wound-healing capabilities of your formulations by performing large screens of analytes predictive of wound healing in conjunction with histology.

The PMM offers a unique way to investigate inflammatory cytokine concentrations in a cost-effective manner. We can perform ELISAs and multiplex assays to determine whether experimental compounds are pro- or anti-inflammatory.

We use our porcine skin model to study inflammation by testing the tissue for known biomarkers associated with inflammatory processes. We can apply experimental formulations onto large or small areas of skin and then harvest uniformly sized explants with a biopsy punch. These explants are analyzed for inflammatory cytokine production.

Our human skin model is an excellent way to examine the influence of your experimental product on inflammation. Our wounded or intact human skin models will help determine whether your compounds have pro- or anti-inflammatory properties.

Mucosal tissue is an ideal environment for microbial growth, making the PMM an excellent application for testing the efficacy of products to treat infectious disease pathogens. We can test for efficacy against planktonic and biofilm infections with this model.

Porcine skin testing is commonly used to test formulations or compounds that are applied to the skin (e.g., presurgical products). We can track efficacy against host flora or seed the skin with known pathogens and track how they respond to the compound. We can apply this testing to large or small areas of skin.

Our reactors serve as a testing platform for drugs and devices intended to inhibit biofilm formation on abiotic surfaces. We can determine whether or not, and to what degree, bacteria form biofilms in the presence of your materials.

Using our human skin model, we can perform research on known human pathogens. The most common organisms we use are methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii. Infections can be planktonic or biofilm.