We measure changes in concentrations of biomarkers (e.g., cytokines, growth factors, reactive oxygen species, and hydrolytic enzymes) known to be associated with inflammation. It is critically important to consider the host inflammatory response when developing products such as antimicrobial formulations, cosmetics and skincare products, implantable devices, and wound dressings.
- The body responds to foreign bodies, even relatively inert biomaterials, with inflammation, an integral part of the healing process. However, sustained inflammation may indicate chronic infection or foreign body response, resulting in fibrosis, encapsulation, and consequent failure of implantable devices.
- We use ELISA and multiplex assays that can detect up to 50 proteins at once to determine expression trends in biomarkers associated with wound healing, host antimicrobial activity, inflammation, and chronic wound formation.
- We can use known promoters of inflammation such as LPS and SDS to determine whether your formulations reduce or exacerbate chronic inflammation.
- Experiments can be performed on porcine mucosal, porcine skin, or human skin models.